recently, the incidence of infectious nasal diseases tends to decrease with improved nutrition and use of newly developed antibiotics, However, allergic rhinitis is increasing. Although many studies about the pathogenesis of allergic disease have
been
done, definite pathogenesis remains uncertain. Especially the immunologic mechanism of antibody production remains to be proved. Many theories presented that the lymphocyte has main function on the pathogenesis of allergy.
Using immunoassay of monoclonal antibody (by using avidin-biotin complex immunoperoxidase method) in paraffin embedded section from 30 cases, we evaluated the distribution of the T and B lymphocyte on the mucosa of allergic rhinitis and
non-allergic
rhinitis to identify the interrelation between the pathogenesis of allergic diseases and the role of T and B lymphocytes.
@ES The results were as follows:
@EN 1. There were no significant difference between allergic and control group, with regarding to epithelial hyperplasia, thickened basement membrane, infiltration of small round cell and goblet cells in the submucosa.
2. On the mucosa of allergic rhinitis, increased infiltration of eosinophil and mast cells in the submucosal layer were observed, but the difference was not significant.
3. The allergic rhinitis had more T and B lymphocytes(especially, T lymphocyte) than the non-allergic rhinitis but the difference was not significant, statistically.
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